斑马鱼命名规则

Line Designations

斑马鱼品系命名

Each institution that produces fish lines should acquire an institutional line designation. Historically, line designations were assigned to labs, but the proliferation of labs producing fish has resulted in a change to assigning the designations on an institutional basis. All labs producing fish lines at the same institution should seek to share a single institutional line designation.

每一家创制斑马鱼品系的机构都需要申请一个机构命名的品系名称（机构命名代码）。在过去，品系是以实验室为基础命名的，但是由于实验室数量增长，现在品系命名系统以实验室所属机构为基础。同属一家机构的实验室应当协商产生一个共同的机构品系名称（机构命名代码）。

Contact the Nomenclature Coordinator to be assigned a new line designation. Line designations are assigned using these guidelines:

·       A 2-letter designation is preferred, but is not always possible. In that case a 3-letter designation must be chosen.

·       The designation must not conflict with any zebrafish, human or mouse gene or phenotypic designations.

·       The designation must not conflict with any other line designations. For example, t is listed as the designation for Tubingen, but they use most 2-letter designations that begin with "t".

申请新的品系名称，请联系命名协调员。在命名时请参考以下指南：

·       机构命名代码首选2个字母的名称；其次再考虑3个字母的名称。

·       机构命名代码不得与任何斑马鱼、人类或小鼠基因名称或表型名称相冲突。

·       名称命名代码不得与其他已有的名称冲突。例如，t已被注册为Tubingen的代码，但以“t”开头的大多数2个字母组合名称仍可使用。

Allele-specific names for zebrafish mutants are denoted by superscript following the mutant locus symbol. They are formed by the following rules:

·       Dominant mutations are indicated by a d in the first position; a name without a d indicates a recessive allele.

·       The superscript contains a lower-case letter designation corresponding to the institution at which the mutation was isolated (see table below). This will occur either at the beginning of the name (if recessive) or immediately after the d (if dominant).

·       The institution identifer is followed by a unique number for the particular line.

·       Additional letters should not immediately follow the institution designation but may be appended to the number at the end of the name.

·       Only alphanumeric characters should be used in the line designation.

·       Each allele number must be unique. Because each institution has a different letter designation, all lines are uniquely identified. Click on a designation below to see a list of all lines currently associated with that institution.

斑马鱼突变的特定名称应以上标表示，紧跟所突变的基因名称之后。具体规则如下：

·       命名若以d开头则表示该突变为显性突变；否则为隐性突变。

·       当突变名称仅含有一个字母时，这个字母表示创制该突变的机构命名代码（清单见下），如果突变为隐形，则以该字母开头，如突变为显性则在前面加d。

·       机构命名代码其后应跟着唯一的数字编号。

·       （如需增加字母后缀）字母后缀不能紧跟机构命名代码，而应该附加在编码之后。

·       品系命名只能使用字母和数字。

·       每个等位基因的编号必须是唯一的。由于每个机构都有不同的机构命名代码，因此所有品系都是唯一标识的。检索下面的清单表格可以查找全部已有的机构命名代码。

For example, in Eugene, Oregon, all allele names begin with b and are numbered sequentially, approximately in the order that they were identified; cyc^b16 is an allele of cyclops that was isolated in Eugene.

More examples:
Dominant allele from Carnegie Institute - chi^dc124
Recessive alleles from Children's Hospital, Boston - dly^cz3321, egy^cz5
Recessive allele from University of Pennsylvania, with appended letters - bbp^p58cd

For more information, you can refer to the Zebrafish Nomenclature Guidelines. To request a new letter designation for your laboratory, please contact ZFIN.

例如，对于美国俄勒冈州尤金市，所有创制的等位基因名称都以b开头，并按等位基因被创制的顺序编号；cyc^b16是表明这是尤金的研究者创制的cyclops这个基因的突变。

更多例子：

来自卡内基研究所（Carnegie Institute）的显性突变： chi^dc124

来自波士顿儿童医院（Children's Hospital, Boston）的隐性等位基因：dly^cz3321, egy^cz5

来自宾夕法尼亚大学（University of Pennsylvania）的隐性等位基因，它的名称中带有字母后缀： bbp^p58cd

有关更多信息，请参阅斑马鱼命名规则。如您要为实验室申请新的品系名称，请联系ZFIN。